{"id":1112,"date":"2021-05-12T06:23:26","date_gmt":"2021-05-12T00:53:26","guid":{"rendered":"https:\/\/thepktalks.com\/?p=1112"},"modified":"2021-05-13T10:37:05","modified_gmt":"2021-05-13T05:07:05","slug":"anti-covid-drug-2-dg-and-its-benefits","status":"publish","type":"post","link":"https:\/\/www.thepktalks.com\/anti-covid-drug-2-dg-and-its-benefits.html","title":{"rendered":"What is anti Covid drug 2-DG and how it reduces the dependence of patient on oxygen?"},"content":{"rendered":"

DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI) as an adjunct therapy in moderate cases of COVID-19.\u00a0 <\/span><\/p>\n

The 2-DG drug is expected to help hospitalised COVID-19 patients and reduce their supplemental oxygen dependence.<\/span><\/p>\n

The anti-Covid oral drug has been developed by the Defence Research and Development Organisation’s (DRDO’s) leading laboratory- Institute of Nuclear Medicine and Allied Sciences (INMAS) in collaboration with Dr Reddy’s Laboratories.<\/span><\/p>\n

How was 2-DG developed? How were clinical trials conducted?<\/strong><\/span><\/h2>\n

DRDO Project Director and Scientist of 2-DG, Dr Sudhir Chandana explained how the drug was developed. <\/span><\/p>\n

He stated that when the pandemic hit India in April 2020, they discovered that 2-DG halts the spread of COVID-19 inside the body cells.<\/span><\/p>\n

“After the findings, we asked the DCGI for permission to conduct clinical trials. In May 2020, we got permission for the clinical trials. <\/span><\/p>\n

By the end of October 2020 we had completed the second phase of trials, and the results were very good. Using standard care, 2 DG will be more beneficial for the Covid-19 patients.<\/span><\/p>\n

A total of 110 patients were part of the Phase-II clinical trials of DRDO’s 2-DG drug. <\/span><\/p>\n

The results showed that in terms of improvement of vital signs of COVID-19 symptomatic patients there was a difference of 2.5 days compared to Standard of Care (SoC). <\/span><\/p>\n

Approval for Phase – III clinical trials were granted in November 2020. These were conducted in 27 COVID-19 hospitals spread across several states.<\/span><\/p>\n

“Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence,” an official DRDO statement had explained earlier.<\/span><\/p>\n

How 2-DG controls COVID-19 and reduces dependence on oxygen?<\/strong><\/span><\/h2>\n

Explaining how 2-DG controls COVID-19 and reduces dependence on oxygen, Chandana told that , “The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production. <\/span><\/p>\n

The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen”.<\/span><\/p>\n

How will 2-DG be manufactured?<\/strong><\/span><\/h2>\n

The DRDO stated that the 2-deoxy-D-glucose (2-DG) drug can easily be produced in India and made available in plenty to the citizens as it is a generic molecule and analogue of glucose.<\/span><\/p>\n

How is 2-DG be consumed?<\/strong><\/span><\/h2>\n

The anti-COVID drug 2-DG has been developed in powder form and is ingested orally by dissolving it in water.<\/span><\/p>\n

When will this drug be available to patients?<\/strong><\/span><\/h2>\n

Our Industry partner is Dr Reddy\u2019s Laboratories. We are working and trying together to expedite manufacturing. In a few weeks or within a month time, the medicine will be available for the patients.<\/span><\/p>\n

Also read – What is black fungus and how it effects Covid infected patients?<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the…<\/p>\n","protected":false},"author":2,"featured_media":1113,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[55],"tags":[],"yoast_head":"\nWhat is anti Covid drug 2-DG and how it reduces the dependence of patient on oxygen?<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thepktalks.com\/anti-covid-drug-2-dg-and-its-benefits.html\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is anti Covid drug 2-DG and how it reduces the dependence of patient on oxygen?\" \/>\n<meta property=\"og:description\" content=\"DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted 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